ORIGINAL_ARTICLE
Survey of Available Literature and Meta-Analyses on Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is an encapsulated collection of blood and fluid on the surface of the brain. It is a common condition, especially in elderly patients, with an incidence of 58 cases per 100 000 people per year in patients over 65 years of age, a mortality rate of about 2%, and a recurrence rate ranging from 11.7% to 28% despite surgical and medical treatments. Due to the high incidence of CSDH, a vast amount of literature exists on the various medical and surgical aspects. Moreover, the literature contains meta-analyses analyzing different techniques, medical therapies, and factors associated with prognoses. Herein, the available literature and meta-analyses on different aspects of CSDH are reviewed in order to provide a rapid review of the best evidence regarding this condition. Twelve meta-analyses comparing the effects of different surgical and/or medical treatments on various different clinical outcomes were analyzed. Strong evidence was found that: (1) burr-hole craniostomy and twist-drill craniostomy are both efficacious in treating CSDH; (2) drainage placement is associated with better clinical outcomes and significantly lower recurrence rates; (3) antithrombotic drugs are significantly associated with a higher recurrence rate; and (4) in case of need of reoperation, open craniotomy is associated with better outcomes compared with minimally invasive procedures. Further studies are needed to clarify the role of corticosteroids and the best timing of the resumption of antithrombotic drugs after CSDH evacuation.
https://www.ijmedrev.com/article_61358_7eb469facdb9cc4a1e9e002b3c8366cd.pdf
2016-12-24
497
500
10.15171/ijmr.2016.09
Chronic Subdural Hematoma
Surgery
Drug Therapy
Meta-analysis
review
Nicola
Montano
nicolamontanomd@yahoo.it
1
Institute of Neurosurgery, Gemelli University Hospital, Catholic University, Rome, Italy
LEAD_AUTHOR
Eleonora
Ioannoni
2
Institute of Anaesthesiology and Intensive Care Medicine, Gemelli University Hospital, Catholic University, Rome, Italy
AUTHOR
Anselmo
Caricato
3
Institute of Anaesthesiology and Intensive Care Medicine, Gemelli University Hospital, Catholic University, Rome, Italy
AUTHOR
Alessandro
Olivi
4
Institute of Neurosurgery, Gemelli University Hospital, Catholic University, Rome, Italy
AUTHOR
ORIGINAL_ARTICLE
Advances in Research and Application of Liquid Biopsy in Lymphoma
Liquid biopsy as a new rising non-invasive testing method plays an important role in assist of the diagnosis, evaluation of the efficacy and prognosis, monitoring of early recurrence and drug resistance. It has been widely applied in some type of solid tumors. Lymphoma is a group of heterogeneous hematological malignancies which most subtypes without specific tumor markers and evaluation of the efficacy and prognostic is mainly depends on and limited to biopsy and imaging. Compared to other solid tumors, lymphoma tumor cells were characterized with access to peripheral easier and immunoglobulin molecules diversity can be monitored as marker, which is more applicable to liquid biopsy. With advances in the detection technology, research and application of liquid biopsy in lymphoma has attracted more attentions.
https://www.ijmedrev.com/article_61360_85887466c7925da2444cf7090d18aaf0.pdf
2016-12-24
501
503
10.15171/ijmr.2016.10
Liquid Biopsy
Circulating Tumor DNA
Lymphoma
Yang
Zhang
1
Hebei Yanda Lu Daopei Hospital, Langfang, China
AUTHOR
Yu
Zhang
2
Hebei Yanda Lu Daopei Hospital, Langfang, China
AUTHOR
Hongxing
Liu
lhongxing@outlook.com
3
Hebei Yanda Lu Daopei Hospital, Langfang, China
LEAD_AUTHOR
ORIGINAL_ARTICLE
A Review of the Various Suicide Methods Used Around the World
Around 800 000 to 1 million people die by suicide annually, making suicide the 10th leading cause of death worldwide. Suicide rates are higher among men than women, and the probability of suicide is 3 to 4 times higher for men than for women. Non-lethal suicide is more common in young people and women. The type of suicide seen in different countries depends on the culture, economic, and social conditions in the respective country. Also, differences in types of suicide are partly due to the availability of various methods. In recent years, the percentage of suicides has risen in all countries. Surveys show that the most prominent methods of suicide in most countries in the world are hanging and poisoning. The most deadly type of suicide is by gun. The most unsuccessful suicide attempts are overdoses of medication. Knowing about the available suicide methods is important.
https://www.ijmedrev.com/article_61361_41b0ebe1e0b5ae8380089a12cd4b9e84.pdf
2016-12-24
504
507
10.15171/ijmr.2016.11
Suicide
Type of Suicide
Countries
Reza
Bidaki
1
Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Shekoufeh
Shirani
2
Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Mohammad
Shamsian
3
Departments of Psychology, Yazd Branch, Islamic Azad University, Yazd, Iran
AUTHOR
Elham
Poursarkhosh Tezerjani
4
Departments of Psychology, Yazd Branch, Islamic Azad University, Yazd, Iran
AUTHOR
Fariba
Heidari
5
Departments of Psychology, Yazd Branch, Islamic Azad University, Yazd, Iran
AUTHOR
Banafsheh
Shirani
banafshe.shirani@yahoo.com
6
Shahid Sadoughi University of Medical Sciences, Yazd, Iran
LEAD_AUTHOR
Aida
Farsham
7
Clinical Psychology, Alzahra University, Tehran, Iran
AUTHOR
ORIGINAL_ARTICLE
Gene Therapy for Lumbar Disc Disease; An Overview of Animal and Human Studies
Low back pain (LBP), a common disorder involving the muscles, nerves, and bones of the back, is associated with lumbar disc degeneration. It is a complex phenomenon, likely the result of a combination of biochemical and biomechanical factors that are known to occur in discs. However, the findings of previous studies have suggested that disc degeneration may be explained primarily by genetic influences. For this reason, scientists are interested in the use of genes/proteins for the treatment of disc degeneration. Protein-based therapies involve the administration of biologic factors into the intervertebral disc to enhance matrix synthesis, postpone degeneration, and prevent inflammation. These factors can be delivered by an intradiscal injection, alone or in combination with cells or tissue scaffolds, and by gene therapy. A systematic search for articles dated from 1990 to the present was performed to identify pertinent articles related to the topic of the role of gene therapy in treating intervertebral disc degeneration. Twenty-seven studies reported the use of at least one gene in treating this disease through gene therapy. Researchers have been performing phases I/II of a clinical trial on the treatment of disc degeneration with gene therapy since 2008. Recent studies have shown that gene therapy may have promise as a method of slowing down or preventing some of the changes seen in intervertebral discs. However, because the clinical trial is not complete and therefore the results are indeterminate, this method cannot be proffered as a replacement for surgery. It is hoped that definitive results of the possible effects of gene therapy on the human body will be acquired soon.
https://www.ijmedrev.com/article_61362_0bcb93c2ffeaca43d0936aef691021c6.pdf
2016-12-24
508
514
10.15171/ijmr.2016.12
Gene Therapy
Lumbar Disc Disease
Majid
Rezvani
1
Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Laleh
Beigi
2
Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Masih
Saboori
3
Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Sheida
Ebrahimi
4
Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Mohammad Reza
Akrami
5
Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Saeed
Oraee-Yazdani
6
Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Comprehensive Center of Excellence, Shahid Beheshti University of Medical Sciences,Tehran,Iran
AUTHOR
Soheil
Tahani
7
Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Shima
Shadabi
8
Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Leila
Dehghani
l_dehghani2002@yahoo.com
9
Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Injuries to the Celiac Trunk: A Systematic Review of Trauma to Haller’s Tripod
Introduction: The celiac artery is nestled deep within the abdomen and provides blood flow to the foregut. Injuries to the celiac artery are rare and carry a high mortality rate.
Methods: A systematic MEDLINE Complete literature search was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Relevant studies, specifically those focusing on diagnosis and management of traumatic celiac arterial injuries were selected, excluding pediatric and iatrogenic cases. Studies from all years were considered, given the paucity of literature on this topic. Studies included in the review were categorized according to level of evidence.
Results: The initial search yielded 5295 results. Specifiers and removing duplicates reduced this number to a final result of 226 studies. After applying exclusion criteria, there were 33 remaining studies containing a total of 175 patients. Of these, only 5 had greater than ten patients in the study, and the majority of the remaining studies were level IV and V evidence. Of the studies reporting deaths, the overall mortality was 34%.
Conclusion: Injuries to the celiac artery are very rare and occur as a result of penetrating or blunt trauma. These injuries carry a high mortality rate and early recognition requires a high index of suspicion. Diagnosis is based on CT imaging or direct visualization during an exploratory laparotomy. Treatment modalities include open repair, endovascular repair, ligation and medical management. Currently, given the lack of available studies, there is no uniform or agreed-upon treatment approach.
https://www.ijmedrev.com/article_61363_d95c1b246881970f366a36cf7e5ea3e0.pdf
2016-12-24
5015
522
10.15171/ijmr.2016.13
Bradley
Phillips
bjpmd02@gmail.com
1
CHSi International, Baghdad Embassy Hospital, Baghdad, Iraq
LEAD_AUTHOR
Lauren
Turco
2
Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA
AUTHOR
Shelby
Reiter
3
Department of Surgery, Swedish Medical Center, Seattle, Washington, USA
AUTHOR
Erin
Murray
4
Department of Orthopedic Surgery, University of Missouri-Kansas City Medical Center, Kansas City, Kansas, USA
AUTHOR
Dan
McDonald
5
Department of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
AUTHOR
David
Cornell
6
Department of Surgery, Creighton University School of Medicine, Omaha, Nebraska, USA
AUTHOR
Juan
Asensio
7
Department of Surgery, Creighton University School of Medicine, Omaha, Nebraska, USA
AUTHOR
ORIGINAL_ARTICLE
The History and Efficacy of Intravitreal Injection of Pegaptanib in Patients With Macular Edema Secondary to Branch Retinal Vein Occlusion; The Need for Special Attention
https://www.ijmedrev.com/article_61364_2d4612e486fd0154bdc8254eb6241b7e.pdf
2016-12-01
523
524
10.15171/ijmr.2016.14
Roohollah
Ahmadian
1
Student Research Committee, Baqiyatallah University of Medical Science, Tehran, Iran
AUTHOR
Shahriar
Najafizadeh-Sari
dr.najafi73@yahoo.com
2
Student Research Committee, Baqiyatallah University of Medical Science, Tehran, Iran
LEAD_AUTHOR