Document Type: Narrative Review
Medical Faculty of Udayana University, Denpasar, Bali, Indonesia
Endocrinology and Metabolism Division, Department of Internal Medicine, Medical Faculty of Udayana University/Sanglah Hospital, Denpasar, Bali, Indonesia
Type 1 Diabetes Mellitus (T1DM) is an autoimmune disorder which results in the INS pancreatic β-cell destruction and contributes to around 5 to 10% of all diabetes mellitus cases, especially in children. At the moment, the only treatment for T1DM is by insulin injection, which is injected in order to prevent the complication of T1DM. However, several studies have shown that combination between Embryonic Stem Cells (ESCs) and the Fibroblast Growth Factor 2 (FGF-2) may be a successful modality to treat T1DM. Actually, the ESCs may become the potential therapy in treating T1DM.