Background: Some studies have shown that probiotics reduce the incidence of Necrotizing enterocolitis (NEC) and sepsis; while other studies have not shown a significant difference of NEC and sepsis incidence. There are still no protocols or guidelines for the use of routine probiotics in Very Low Birth Weight (VLBW) preterm infants. Objective: A meta-analysis was assessed by reviewing up to date Randomized Controlled Trials (RCTs) to investigate the effectiveness of probiotics to prevent NEC. Data Sources: The Pubmed, Proquest, and Cochrane Library databases were searched from 2009 to 2019. Study selection: This meta-analysis was assessed according to PRISMA guidelines. Data extraction: The inclusion criteria included RCTs of probiotics for very low birth weight preterm babies; full text English articles; and those manuscripts published within the year of 2009 to 2019. Results: The present research included nine studies. The incidence of NEC in the probiotic group were significantly lower (P = <0.00001, R = 0.48). In the subgroup analysis, the incidence of NEC was lower in the multiple strain group and lactobacillus group with P = 0.0004 and 0.006 respectively. The incidence of sepsis was lower in the probiotic group with P = 0.02; and the incidence of all-cause mortality was lower in the probiotic group with P = 0.02. Conclusion: According to findings it can be stated that it is beneficial to use multiple strain probiotics and lactobacillus strain probiotics to prevent NEC in VLBW preterm babies.
Kurnia, B., & Rusli, R. (2022). Prevention of Necrotizing Enterocolitis in Very Low Birth Weight Preterm Infants with Probiotics: a Systematic Review and Metaanalysis. International Journal of Medical Reviews, 9(1), 201-206. doi: 10.30491/ijmr.2022.147110
MLA
Bella Kurnia; Richardo Rusli. "Prevention of Necrotizing Enterocolitis in Very Low Birth Weight Preterm Infants with Probiotics: a Systematic Review and Metaanalysis". International Journal of Medical Reviews, 9, 1, 2022, 201-206. doi: 10.30491/ijmr.2022.147110
HARVARD
Kurnia, B., Rusli, R. (2022). 'Prevention of Necrotizing Enterocolitis in Very Low Birth Weight Preterm Infants with Probiotics: a Systematic Review and Metaanalysis', International Journal of Medical Reviews, 9(1), pp. 201-206. doi: 10.30491/ijmr.2022.147110
VANCOUVER
Kurnia, B., Rusli, R. Prevention of Necrotizing Enterocolitis in Very Low Birth Weight Preterm Infants with Probiotics: a Systematic Review and Metaanalysis. International Journal of Medical Reviews, 2022; 9(1): 201-206. doi: 10.30491/ijmr.2022.147110
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