Recent Advances in the Early Diagnosis of Oral Cancer: A Systematic Review

Document Type: Systematic Review

Authors

Department of Public Health Dentistry, Sibar Institute of Dental Sciences, Guntur, India

Abstract

Introduction: Oral cancer survival rates are strongly dependent upon the stage in which the diagnosis is being made. Patients diagnosed with oral cancer within the localized stage have a substantially greater chance of successful treatment, and there is a greater chance of morbidity if the patient is diagnosed with cancer in later stages. Successful early detection symbolizes one of the superlative techniques which would eventually increase the oral cancer survival rate and quality of life worldwide. This study aimed to illustrate and provide awareness of current trends and recent advances in early diagnostic tools of oral cancer and to differentiate the validity of diverse initial detection methods.
Methods: This research is a systematic review. The evaluation was confined to articles published in the past 15 years (i.e. 1999-2016). Searches were conducted both manually and electronically. A “manual exploration” was made by methodically examining key journals available in the library of the institution; documents and data were retrieved from the online databases PubMed and Google Scholar.
Results: In total, 19 articles were reviewed.
Conclusions: Oral cancer detection techniques can provide real-time diagnoses and are non-invasive. At present, large multicenter trials are necessary to determine the sensitivity and specificity of these individual and combined techniques and to evaluate and develop their ability to detect and manage potentially malignant and malicious oral lesions.

Keywords

References

  1. Lipkin A, VeriMed Healthcare Network. Oral Cancer 2018 [updated 2018; cited 2018]. Available from: https://www.healthcentral.com/encyclopedia/o/oral-cancer.
  2. Shin D, Vigneswaran N, Gillenwater A, Richards-Kortum R. Advances in fluorescence imaging techniques to detect oral cancer and its precursors. Future Oncol. 2010;6(7):1143-54. doi: 10.2217/fon.10.79. pmid: 20624126.
  3. Nitish Grag K, Singhal K. Potentially Oral Malignant Lesion and Oral Cancer and Future Diagnostic Techniques: A Review. Indian J Appl Res. 2013;3(6):421-5.
  4. Omar EA. The outline of prognosis and new advances in diagnosis of oral squamous cell carcinoma (OSCC): review of the literature. J Oral Oncol. 2013;3(2):1-13. doi: 10.1155/2013/519312.
  5. Du GF, Li CZ, Chen HZ, Chen XM, Xiao Q, Cao ZG, et al. Rose bengal staining in detection of oral precancerous and malignant lesions with colorimetric evaluation: a pilot study. Int J Cancer. 2007;120(9):1958-63. doi: 10.1002/ijc.22467. pmid: 17245698.
  6. Fedele S. Diagnostic aids in the screening of oral cancer. Head Neck Oncol. 2009;1:5. doi: 10.1186/1758-3284-1-5. pmid: 19284694.
  7. Malignant - definition of malignant by The Free Dictionary 2018 [updated 2018; cited 2018]. Available from: https://www.thefreedictionary.com/malignant.
  8. World Health Organization. Cancer - World Health Organization 2018 [updated 2018; cited 2014]. Available from: http://www.who.int/news-room/fact-sheets/detail/can cer.
  9. Park K. Park's Textbook of Preventive and Social Medicine. Jabalpur: Bhanot Publishers; 2017.
  10. Chen YW, Lin JS, Wu CH, Lui MT, Kao SY, Fong Y. Application of in vivo stain of methylene blue as a diagnostic aid in the early detection and screening of oral squamous cell carcinoma and precancer lesions. J Chin Med Assoc. 2007;70(11):497-503. doi: 10.1016/S1726-4901(08)70048-0. pmid: 18063504.
  11. Gupta M, Gupta M, Aggarwal A, Ahuja R. Recent advancements in the diagnosis of oral premalignant and malignant lesions: A comprehensive review. Clin Cancer Invest J. 2013;2(3):181. doi: 10.4103/2278-0513.119249.
  12. Masthan KM, Babu NA, Dash KC, Elumalai M. Advanced diagnostic aids in oral cancer. Asian Pac J Cancer Prev. 2012;13(8):3573-6. doi: 10.7314/APJCP.2012.13.8.3573. pmid: 23098535.
  13. Sciubba JJ. Improving detection of precancerous and cancerous oral lesions. Computer-assisted analysis of the oral brush biopsy. U.S. Collaborative OralCDx Study Group. J Am Dent Assoc. 1999;130(10):1445-57. pmid: 10570588.
  14. Scheifele C, Schmidt-Westhausen AM, Dietrich T, Reichart PA. The sensitivity and specificity of the OralCDx technique: evaluation of 103 cases. Oral Oncol. 2004;40(8):824-8. doi: 10.1016/j.oraloncology.2004.02.004. pmid: 15288838.
  15. Ram S, Siar CH. Chemiluminescence as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions. Int J Oral Maxillofac Surg. 2005;34(5):521-7. doi: 10.1016/j.ijom.2004.10.008. pmid: 16053872.
  16. Bhalang K, Suesuwan A, Dhanuthai K, Sannikorn P, Luangjarmekorn L, Swasdison S. The application of acetic acid in the detection of oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(3):371-6. doi: 10.1016/j.tripleo.2008.01.017. pmid: 18547833.
  17. Allegra E, Lombardo N, Puzzo L, Garozzo A. The usefulness of toluidine staining as a diagnostic tool for precancerous and cancerous oropharyngeal and oral cavity lesions. Acta Otorhinolaryngol Ital. 2009;29(4):187-90. pmid: 20161875.
  18. Nagaraju K, Prasad S, Ashok L. Diagnostic efficiency of toluidine blue with Lugol's iodine in oral premalignant and malignant lesions. Indian J Dent Res. 2010;21(2):218-23. doi: 10.4103/0970-9290.66633. pmid: 20657091.
  19. Awan KH, Morgan PR, Warnakulasuriya S. Utility of chemiluminescence (ViziLite) in the detection of oral potentially malignant disorders and benign keratoses. J Oral Pathol Med. 2011;40(7):541-4. doi: 10.1111/j.1600-0714.2011.01048.x. pmid: 21615500.
  20. Awan KH, Morgan PR, Warnakulasuriya S. Evaluation of an autofluorescence based imaging system (VELscope) in the detection of oral potentially malignant disorders and benign keratoses. Oral Oncol. 2011;47(4):274-7. doi: 10.1016/j.oraloncology.2011.02.001. pmid: 21396880.
  21. Mehrotra R, Gupta DK. Exciting new advances in oral cancer diagnosis: avenues to early detection. Head Neck Oncol. 2011;3:33. doi: 10.1186/1758-3284-3-33. pmid: 217980 30.
  22. Cancela-Rodriguez P, Cerero-Lapiedra R, Esparza-Gomez G, Llamas-Martinez S, Warnakulasuriya S. The use of toluidine blue in the detection of pre-malignant and malignant oral lesions. J Oral Pathol Med. 2011;40(4):300-4. doi: 10.1111/j.1600-0714.2010.00985.x. pmid: 214264 01.
  23. Rana M, Zapf A, Kuehle M, Gellrich NC, Eckardt AM. Clinical evaluation of an autofluorescence diagnostic device for oral cancer detection: a prospective randomized diagnostic study. Eur J Cancer Prev. 2012;21(5):460-6. doi: 10.1097/CEJ.0b013e32834fdb6d. pmid: 22217551.
  24. Upadhyay J, Rao NN, Upadhyay RB, Agarwal P. Reliability of toluidine blue vital staining in detection of potentially malignant oral lesions--time to reconsider. Asian Pac J Cancer Prev. 2011;12(7):1757-60. pmid: 22126560.
  25. Ujaoney S, Motwani MB, Degwekar S, Wadhwan V, Zade P, Chaudhary M, et al. Evaluation of chemiluminescence, toluidine blue and histopathology for detection of high risk oral precancerous lesions: A cross-sectional study. BMC Clin Pathol. 2012;12:6. doi: 10.1186/1472-6890-12-6. pmid: 22410295.
  26. Riaz A, Shreedhar B, Kamboj M, Natarajan S. Methylene blue as an early diagnostic marker for oral precancer and cancer. Springerplus. 2013;2(1):95. doi: 10.1186/2193-1801-2-95. pmid: 23524482.
  27. Reddy SP, Ramani P, Nainani P. Confocal microscopy and exfoliative cytology. J Oral Maxillofac Pathol. 2013;17(2):217-21. doi: 10.4103/0973-029X.119746. pmid: 24250082.
  28. Madbhavi S, Rupnarayan R, SM AM. Efficacy of toluidine blue and brush biopsy in oral lesions. Int J Oral Maxillofac Pathol. 2013;4(1):2-8.
  29. Vashisht N, Ravikiran A, Samatha Y, Rao PC, Naik R, Vashisht D. Chemiluminescence and Toluidine Blue as Diagnostic Tools for Detecting Early Stages of Oral Cancer: An invivo Study. J Clin Diagn Res. 2014;8(4):ZC35-8. doi: 10.7860/JCDR/2014/7746.4259. pmid: 24959513.
  30. Bhandary S, Bhandary P. Cancer of the oral cavity- a growing concern in the Micronesia: a case report from the MarshallIslands. Pac Health Dialog. 2003;10(1):76-8. pmid: 16276948.
  31. Scott IS, Odell E, Chatrath P, Morris LS, Davies RJ, Vowler SL, et al. A minimally invasive immunocytochemical approach to early detection of oral squamous cell carcinoma and dysplasia. Br J Cancer. 2006;94(8):1170-5. doi: 10.1038/sj.bjc.6603066. pmid: 16622441.
  32. Ribeiro IP, Barroso L, Marques F, Melo JB, Carreira IM. Early detection and personalized treatment in oral cancer: the impact of omics approaches. Mol Cytogenet. 2016;9:85. doi: 10.1186/s13039-016-0293-1. pmid: 27895714.
  33. Koneru S, Tanikonda R. Salivaomics - A promising future in early diagnosis of dental diseases. Dent Res J (Isfahan). 2014;11(1):11-5. pmid: 24688554.
  34. Pujari M, Bahirwani S, Balaji P, Kaul R, Shah B, Daryani D, et al. Oral fluid nanosensor test: saliva as a diagnostic tool for oral health. J Calif Dent Assoc. 2012;40(9):733-6. pmid: 23097828.
International Journal of Medical Reviews

Volume 4, Issue 4
Autumn 2017
Pages 119-125

Files

History

  • Receive Date: 24 October 2017
  • Revise Date: 24 November 2017
  • Accept Date: 02 December 2017

Share

How to cite

Statistics