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International Journal of Medical Reviews
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Ramezani, M., Tavallai, M., Zargari, P., Bahmani, H., Habibi, S., Khafaei, M., Salehi, Z., Tabkhi, R., Chavoshi, S., Ghotbi, A., Ghotbi, F., Mohammadi, A. (2018). Genetic Analysis and Genealogy of Ancient Bone Samples. International Journal of Medical Reviews, 5(3), 130-134. doi: 10.29252/IJMR-050306
Maryam Ramezani; Mahmood Tavallai; Peyman Zargari; Hasan Bahmani; Sajad Habibi; Mostafa Khafaei; Zeinab Salehi; Raheleh Tabkhi; Somaieh Chavoshi; Atefeh Ghotbi; Fatemeh Ghotbi; Ali Mohammadi. "Genetic Analysis and Genealogy of Ancient Bone Samples". International Journal of Medical Reviews, 5, 3, 2018, 130-134. doi: 10.29252/IJMR-050306
Ramezani, M., Tavallai, M., Zargari, P., Bahmani, H., Habibi, S., Khafaei, M., Salehi, Z., Tabkhi, R., Chavoshi, S., Ghotbi, A., Ghotbi, F., Mohammadi, A. (2018). 'Genetic Analysis and Genealogy of Ancient Bone Samples', International Journal of Medical Reviews, 5(3), pp. 130-134. doi: 10.29252/IJMR-050306
Ramezani, M., Tavallai, M., Zargari, P., Bahmani, H., Habibi, S., Khafaei, M., Salehi, Z., Tabkhi, R., Chavoshi, S., Ghotbi, A., Ghotbi, F., Mohammadi, A. Genetic Analysis and Genealogy of Ancient Bone Samples. International Journal of Medical Reviews, 2018; 5(3): 130-134. doi: 10.29252/IJMR-050306

Genetic Analysis and Genealogy of Ancient Bone Samples

Article 6, Volume 5, Issue 3, Summer 2018, Page 130-134  XML PDF (654.47 K)
Document Type: Narrative Review
DOI: 10.29252/IJMR-050306
Authors
Maryam Ramezani; Mahmood Tavallai; Peyman Zargari; Hasan Bahmani; Sajad Habibi; Mostafa Khafaei; Zeinab Salehi; Raheleh Tabkhi; Somaieh Chavoshi; Atefeh Ghotbi; Fatemeh Ghotbi; Ali Mohammadi email
Human Genetics Research Center, Baqiyatallah University of Medical Sciences Tehran, Iran
Receive Date: 03 July 2018,  Revise Date: 01 September 2018,  Accept Date: 04 September 2018 
Abstract
The analysis of ancient DNA (aDNA) can inspire both the public and the scientific community. Knowing about ancient human genomes and comparing them with those of modern humans can give us a new perspective on evolution and the migration of humans over time. aDNA is DNA isolated from ancient specimens. It can also be loosely described as any DNA recovered from biological samples that have not been preserved specifically for later DNA analysis. Examples include DNA recovered from archaeological and historical skeletal material, mummified tissues, archival collections of non-frozen medical specimens, preserved plant remains, ice and permafrost cores, Holocene plankton in marine and lake sediments, and so on. Due to considerable anthropological, archaeological, and public interest, human remains receive ample attention from the DNA community. Genetic genealogy is the use of DNA testing in combination with traditional genealogical methods to infer relationships between individuals and to find ancestors. Genetic genealogy involves the use of genealogical DNA testing to determine the level and type of genetic relationship between individuals. DNA markers such as autosomal single nucleotide polymorphisms (SNPs), Y SNPs, and mitochondrial DNA (mtDNA) SNPs are used. By analyzing the sequence of mtDNA and the Y-chromosome, the path of human migration throughout history and the common ancestor of humans can be identified. mtDNA analysis is a field of research in genetics and molecular archaeology that is efficient in less than ideal conditions, such as with biologically degraded materials. The mtDNA molecule not only has a high copy number, but it can also be extracted from very decayed biological specimens. Its D-loop region is polymorphic, consisting of two hypervariable regions (HVI and HVII) with a large variety in different human populations. The analysis of such mtDNA regions using ancient excavated human bones will determine the genetic composition of human mtDNA known as haplogroups and can be used to identify ancient ethnic groups, trace descendants of ancestors, and follow man’s migration trails.
Keywords
Ancient DNA; Genealogy; DNA Markers; mtDNA; SNPs; Y Chromosome
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