Organizational culture and technological integration are widely recognized as critical drivers of healthcare organizational performance, particularly in the context of accelerating digital transformation. This review examines how alignment between organizational culture and technological initiatives influences performance outcomes in healthcare organizations. Drawing on empirical studies and healthcare case evidence, the review identifies four recurring barriers to effective digital transforma tion: resistance to change, financial and infrastructural constraints, interoperability challenges, and limited digital competencies among healthcare professionals. The findings indicate that healthcare organizations characterized by strong leadership engagement, adaptive cultures, and structured change-management practices achieve higher levels of technology adoption, improved operational efficiency, enhanced patient safety, and better quality of care . Importantly, the review demonstrates that technology alone does not lead to sustainable performance improvement; its effectiveness is largely shaped by organizational culture, leadership alignment, and continuous workforce development. Based on these findings, the review recommends strengthening leadership commitment, embedding formal change-management frameworks, investing in continuous staff training, and promoting cross-sector collaboration to support sustainable digital transformation. Overall, integrating cultural transformation with technological innovation is essential for building resilient, efficient, and high -performing healthcare organizations.