International Journal of Medical Reviews

International Journal of Medical Reviews

Efflux Pump Inhibitors Derived From Natural Sources as Novel Antibacterial Agents Against Pseudomonas aeruginosa: A Review

Document Type : Narrative Review

Authors
Davood Iman Islamieh 1
Davoud Afshar 2
Masoud Yousefi 3
Davoud Esmaeili 1
1 Department of Microbiology and Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
2 Department of Microbiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
3 Department of Microbiology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
10.29252/IJMR-050303
Abstract
Infections resulting from Pseudomonas aeruginosa are important due to their highest resistance against all clinically used antibiotics. To date, 11 different efflux pumps of the RND family in P. aeruginosa that enable the efflux of antibiotics/anti-microbial production have been detected. Carvacrol of Satureja khuzestanica is one of the most effective compounds with the ability to affect bacteria. This study aimed to evaluate herbal compounds with inhibitory activities. These pumps include MexAB-OprM, MexCD-OprJ, MexEF-OprN, MexGHI-OpmD, MexJK-OprM/OpmH, MexMN, MexPQ-OpmE, MexVW-OprM, MexXY-OprM, TriABC-OpmH, and MuxABC-OpmB (1). Unfortunately, among bacteria, P. aeruginosa are highly resistant to drug compounds (3). Because of this high resistance, its importance in nosocomial infections and burns, and that it often causes diseases in immunocompromised patients, finding a therapeutic supplement is essential. In this study, drug compounds against efflux pump genes were sought.
Keywords
Efflux Pump
Pseudomonas aeruginosa
Antibacterial
Mex
Natural
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International Journal of Medical Reviews
Volume 5, Issue 3
Summer 2018
Pages 94-105

  • Receive Date 17 May 2018
  • Revise Date 01 July 2018
  • Accept Date 04 July 2018