Baqiyatallah University of Medical Sciences International Journal of Medical Reviews 2345-525X 7 1 2020 01 01 Transfection of Exogenous Fibroblast Growth Factor (FGF) on Human Embryonic Stem Cells (ESCs) as a Regenerative Agent for Patients with Type 1 Diabetes Mellitus (T1DM) 11 14 107188 10.30491/ijmr.2020.219730.1077 EN John Nolan Medical Faculty of Udayana University, Denpasar, Bali, Indonesia Audrey Wijaya Medical Faculty of Udayana University, Denpasar, Bali, Indonesia Agatha Lianto Medical Faculty of Udayana University, Denpasar, Bali, Indonesia Made Saraswati Endocrinology and Metabolism Division, Department of Internal Medicine, Medical Faculty of Udayana University/Sanglah Hospital, Denpasar, Bali, Indonesia Journal Article 2019 11 02 Type 1 Diabetes Mellitus (T1DM) is an autoimmune disorder which results in the INS pancreatic β-cell destruction and contributes to around 5 to 10% of all diabetes mellitus cases, especially in children. At the moment, the only treatment for T1DM is by insulin injection, which is injected in order to prevent the complication of T1DM. However, several studies have shown that combination between Embryonic Stem Cells (ESCs) and the Fibroblast Growth Factor 2 (FGF-2) may be a successful modality to treat T1DM. Actually, the ESCs may become the potential therapy in treating T1DM. https://www.ijmedrev.com/article_107188_a6c6671bb25e51d6d95712fe85e138b3.pdf