Baqiyatallah University of Medical Sciences International Journal of Medical Reviews 2345-525X 7 2 2020 04 01 Biochemical and Haematological Changes in Wistar Rats after Administration of Nickel- and Copper-Drug Complexes of Isonicotinic Acid Hydrazide 64 70 110467 10.30491/ijmr.2020.222172.1080 EN Mercy Bamigboye Department of Industrial Chemistry, University of Ilorin, Ilorin Kwara State Nigeria. 0000-0003-1427-9076 Ayodeji Luqman Quadri Department of Biochemistry, University of Ilorin, Ilorin, Nigeria. Ikechukwu Peter Ejidike Department of Chemical Sciences, Faculty of Science and Science Education, Anchor University Lagos, Nigeria. Risikat Nike Ahmed Department of Microbiology, University of Ilorin, Ilorin Kwara state Nigeria. Journal Article 2020 03 03 <span class="fontstyle0">Metal ion complexes of synthetic drugs are gaining global attention because of their effectiveness in the management of various ailments. Copper<br />and Nickel drug complexes of Isonicotinic Acid Hydrazide were synthesized and investigated for their toxicological activities in Wistar rats using<br />biochemical and haematological parameters. Thirty (30) Wistar rats (150.20 ± 3.42 g) were used and divided into 6 groups (A-F) each containing<br />5 rats. Groups A and B rats orally received 5% DMSO and 20 mg/kg body weight of Isonicotinic Acid Hydrazide respectively, while those in<br />groups C and D received 20 and 40 mg/kg body weight of Ni (ISO)Cl2 respectively. Rats in groups E and F received same doses as in C and D but<br />corresponding to Cu (ISO)Cl2. Each group received 0.5 ml corresponding to the agents administered to them for 21 days. The toxicity in the<br />animals were monitored using standard methods. The ligand and its complexes dose-independently reduced (P < 0.05) serum activities of Alkaline<br />Phosphatase (ALP) as well as quantities of total cholesterol and Red Blood Cells (RBC) but did not significantly (P > 0.05) affect parameters such<br />as tissue ALP activities, direct bilirubin, total bilirubin, creatinine, urea, high density lipoprotein-cholesterol (HDL-C), low density lipoproteincholesterol (LDL-C), atherogenic index, haematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean<br />corpuscular haemoglobin concentration (MCHC). This study has scientifically established the safety of nickel and copper complexes of isonicotinic<br />acid hydrazide. However, caution must be taken in their consumption since they possess hypocholesterolemic properties.</span> <br /><br /> https://www.ijmedrev.com/article_110467_7326d962c3e55cc0b528f327bd65f0a2.pdf