Baqiyatallah University of Medical Sciences International Journal of Medical Reviews 2345-525X 9 4 2022 12 01 Clinical Trial of Combined Thymus daenensis Celak and Ziziphus Jujube Mill Syrup in Primary Hypertension 406 413 164186 10.30491/ijmr.2022.336998.1237 EN Davoud Hasani Department of Persian Medicine, Zanjan University of Medical Sciences, Zanjan, Iran 0000-0002-4047-6439 Hassan Ahanghar Department of Cardiology, Zanjan University of Medical Sciences, Zanjan, Iran Mohsen Bahrami Department of Persian Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Sadrollah Ramezani Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran University of Sistan and Baluchestan, Zahedan, Iran 0000-0001-9254-0511 Mohammad Kamalinejad School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran Elham Faghihzadeh Department of Biostatistics and Epidemiology, Zanjan University of Medical Sciences, Zanjan, Iran Journal Article 2022 04 10 Introduction: Hypertension is the most important disease that can cause heart failure, renal dysfunction, stroke and sodden death in a large population throughout the world. The excessive side effects of the chemical drugs that are used in the treatment of hypertension have attracted attention to herbal medicine. Methods: This study was designed as a randomized clinical trial on both males and females with first and second stage of hypertension. The patients who met inclusion criteria and none of the exclusion criteria were enrolled in the study. The patients were allocated with random blocked dividing between the case and control group with the same group size. The patients in the control group used placebo and patients in case group used mixed therapeutic syrup of Ziziphus Jujube and Thymus daenensis Celak. The syrup was used twice a day with a dose of 5 ml for each time. In order to study the effects of Ziziphus and Thymus on blood biomarkers, it was checked in two stages. Results: Findings reveal that the mixture of herbal syrup could significantly reduce Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) in hypertensive patients (p = 0.002). The reduction in SBP and DBP at the end of the study was 11.84 and 8.03 mmHg, respectively. Also, the mean arterial pressure compared to the baseline decreased to 8.35%. Regards to other parameters, the results of the experiments at the beginning and end of the study showed that Complete Blood Count (CBC), Fasting Blood Sugar (FBS), cholesterol, low-Density Lipoproteins (LDL), High-Density Lipoprotein (HDL), Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP), Blood Urea Nitrogen (BUN), and creatinine were in the normal laboratory range. Conclusion: According to results it can be stated that jujube and thyme can be considered as a miraculous combination in Cardiovascular Disease, Persian Traditional Medicine, Blood Pressure, Thymus Daenensis, Ziziphus Jjujube controlling blood pressure, to minimize secondary complications caused by hypertension.

https://www.ijmedrev.com/article_164186_f3152ad9fcda814e1e7e94a6e7544f47.pdf