Baqiyatallah University of Medical Sciences International Journal of Medical Reviews 2345-525X 12 4 2025 12 01 Pathogenesis of Vitamin D Deficiency in Female Fertility: The Impact on Mast Cell Function 1002 1011 240568 10.30491/ijmr.2025.541297.1347 EN Zahra Mosayebi Student Research Committee, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Nasim Beigi-boroujeni Razi Herbal Medicines Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Negar Azadi Razi Herbal Medicines Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Mandana Beigi-boroujeni Razi Herbal Medicines Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Journal Article 2025 08 14 Introduction:  Mast cells, through the repair of inflammatory mediators, cause structural and functional changes in the female <br>reproductive  system;  however,  unregulated  mast  cell  activity  can  lead  to  fertility  problems  in  women.  On  the  other  hand, <br>vitamin D, due to its modulatory role on mast cell function, may influence pregnancy success rates.<br>Methods: The present study is a narrative review conducted using that incorporates observational studies (both descriptive and <br>analytical) from the past 25 years (2000–2025).  A total of 53 articles indexed in databases such as SID, Science  Direct, Iran <br>medex, Google Scholar, Scopus, and PubMed were reviewed.<br>Results:  Studies  have  shown  that  vitamin  D,  by  reducing  mast  cell  activity  and  inhibiting  the  production  of  inflammatory <br>cytokines, can help improve fertility by decreasing inflammation. Based on the available evidence, vitamin D may be considered<br>an  inflammatory  a  regulator  of  inflammation  in  reproductive  health.  However,  further  research  is  required  to  completely <br>understand the precise mechanisms by which vitamin D affects mast cell activity.<br>Conclusion:  Given  the  role  of  vitamin  D  in  enhancing  folliculogenesis,  hormonal  regulation,  and  its  anti-inflammatory  and <br>antioxidant properties within the ovaries, existing studies suggest that vitamin D treatment may help regulate the number and<br>activity  of  mast  cells  in  the  endometrium  of  ovulation-induced  mice.  This  regulation  can  prevent  excessive  inflammation, <br>improve the uterine environment for embryo implantation, and ultimately increase the success of ovulation and fertility  https://www.ijmedrev.com/article_240568_204013132b4521d76cb3628a50ed5a84.pdf