Baqiyatallah University of Medical Sciences International Journal of Medical Reviews 2345-525X 12 4 2025 12 01 Teucrium polium Extracts are Used as Antidiabetic Medication 1047 1052 240574 10.30491/ijmr.2025.520133.1328 EN Roohallah Yousefi Behbahan Faculty of Medical Sciences, Behbahan, Iran 0000-0002-1547-6752 Journal Article 2025 04 29 Diabetes  mellitus  is  a  long-term  condition  that  causes  high  blood  sugar,  with  type  2  diabetes  (T2DM)  presenting  special <br>problems  due  to  insulin  issues.  Treatment  aims  to  manage  blood  sugar  through  lifestyle  changes  and  medications,  but  side <br>effects  of  current  drugs  have  led  to  interest  in  new  options.  Many  patients,  especially  in  developing  countries,  use  herbal <br>remedies like Teucrium Polium (Tp), which may help but have limited research. Some studies suggest Tp could aid in managing <br>diabetes, though effects are unclear, and safety concerns exist, indicating a need for more research on its effects on insulin and <br>glucose metabolism. To investigate the effectiveness of  Tp in treating diabetes mellitus, a literature search was conducted using <br>databases such as PubMed, Science Direct, and Scopus, employing relevant keywords. We analyzed the properties and effects <br>of  the  antidiabetic  compounds  in  Tp  utilizing  the  SwissADME  database.  This  study  aimed  to  assess  the  potential  of  Tp  for <br>managing  diabetes.  The  compounds  examined  include  apigenin,  quercetin,  and  cirsimaritin,  each  with  molecular  weights <br>around 300 Daltons and containing 20-23 heavy atoms, sharing similar structures but differing in properties that can assist in <br>diabetes  treatment.  Cirsimaritin  can  easily  penetrate  biological  membranes,  making  it  effective  for  high  blood  sugar,  while <br>apigenin is better suited for addressing low blood sugar. All three compounds are well absorbed during digestion, but rutin h as <br>lower absorption, diminishing its effectiveness. Further research is necessary to explore their interactions and develop enha nced <br>diabetes treatments. https://www.ijmedrev.com/article_240574_0ba3f2f8801744eaa341bacaad1ed392.pdf