Baqiyatallah University of Medical Sciences International Journal of Medical Reviews 2345-525X 13 2 2026 06 01 Olivocochlear System Neurobiology and Pathophysiology in Relation to Psychiatric Disorders: A Perspective 1150 1161 248560 10.30491/ijmr.2025.544342.1348 EN Narmeen Tourman Department of Audiology and Speech Pathology, An-Najah National University, Nablus, Palestine 0009-0003-0617-1919 Journal Article 2025 08 31 Recent research indicates an association between auditory efferent abnormalities and the core symptoms of several psychiatric disorders. Neurobiological and electroacoustic studies further implicate CNTNAP2 gene mutations in these efferent anomalies. The medial olivocochlear bundle (MOCB), originating from the periolivary region surrounding the medial superior olive, regulates outer hair cell activity and modulates basilar membrane motion, thereby influencing cochlear input transmission. Impaired neurotransmission along the MOCB or structural alterations of the medial superior olive may lead to efferent auditory dysfunctions that remain undetected by standard audiological assessments. This review explores these mechanisms in relation to auditory hallucinations, selective mutism, tinnitus, and autism spectrum disorder . https://www.ijmedrev.com/article_248560_c8560eb5ce1fbe8be30e72cd4f7e9231.pdf