The Acquired Immunodeficiency Syndrome (AIDS) damages the immune system and interferes with the body’s ability to fight infections and it is caused by a retrovirus named Human Immunodeficiency Virus (HIV). The patients with HIV/AIDS are currently managed with Highly Active Antiretroviral Therapy (HAART) or a combination Antiretroviral Therapy (cART) which includes Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs), Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs), Protease Inhibitors (PIs), Integrase Strand Transfer Inhibitors (INSTIs), Fusion Inhibitors (FIs) and Chemokine Receptor antagonists (CCR5 antagonists). The World Health Organization (WHO) has suggested systematically testing ethnomedicines against HIV to find more options for the treatment of HIV/AIDS. This review focuses on the potentials of N. sativa in the management of HIV/AIDS. The antiviral potentials of N. sativa have been observed in many in-vivo and in-vitro studies while previous studies have confirmed the immunomodulatory effects of N. sativa. Above all, various pilot studies and case reports have demonstrated that the administration of N. sativa produced complete seroreversion of viral load in many HIV/AIDS patients, miraculously. Hence, N. sativa could be used alone or in combination with HAART therapy to cure the patients with HIV/AIDS.