International Journal of Medical Reviews

International Journal of Medical Reviews

Role of Neurosteroids in Catamenial Epilepsy

Document Type : Narrative Review

Authors
1 HITEC Institute of Medical Sciences, Islamabad, Pakistan
2 Dow International Medical College, Islamabad, Pakistan
3 CMH Lahore, Islamabad, Pakistan
Abstract
Catamenial epilepsy is a hormonally influenced seizure disorder where conventional antiepileptic drugs (AEDs) often show limited
efficacy. Neurosteroids—endogenously synthesized modulators of GABAergic inhibition—represent a promising, mechanismbased  alternative.  During  hormone-sensitive  phases  of  the  menstrual  cycle,  compounds  like  ganaxolone  may  help  restore 
inhibitory balance and enhance seizure control. Its safety profile appears favorable, with only mild side effects. However, m ore 
comprehensive  studies  are  required  to confirm  its  long-term  safety and  potency  in  comparison  with  traditional  antiepileptic 
drugs (AEDs).
Keywords

Volume 12, Issue 4
Autumn 2025
Pages 1040-1046

  • Receive Date 13 May 2025
  • Revise Date 23 July 2025
  • Accept Date 05 August 2025