Diabetes  mellitus  is  a  long-term  condition  that  causes  high  blood  sugar,  with  type  2  diabetes  (T2DM)  presenting  special 
problems  due  to  insulin  issues.  Treatment  aims  to  manage  blood  sugar  through  lifestyle  changes  and  medications,  but  side 
effects  of  current  drugs  have  led  to  interest  in  new  options.  Many  patients,  especially  in  developing  countries,  use  herbal 
remedies like Teucrium Polium (Tp), which may help but have limited research. Some studies suggest Tp could aid in managing 
diabetes, though effects are unclear, and safety concerns exist, indicating a need for more research on its effects on insulin and 
glucose metabolism. To investigate the effectiveness of  Tp in treating diabetes mellitus, a literature search was conducted using 
databases such as PubMed, Science Direct, and Scopus, employing relevant keywords. We analyzed the properties and effects 
of  the  antidiabetic  compounds  in  Tp  utilizing  the  SwissADME  database.  This  study  aimed  to  assess  the  potential  of  Tp  for 
managing  diabetes.  The  compounds  examined  include  apigenin,  quercetin,  and  cirsimaritin,  each  with  molecular  weights 
around 300 Daltons and containing 20-23 heavy atoms, sharing similar structures but differing in properties that can assist in 
diabetes  treatment.  Cirsimaritin  can  easily  penetrate  biological  membranes,  making  it  effective  for  high  blood  sugar,  while 
apigenin is better suited for addressing low blood sugar. All three compounds are well absorbed during digestion, but rutin h as 
lower absorption, diminishing its effectiveness. Further research is necessary to explore their interactions and develop enha nced 
diabetes treatments.