Document Type: Mini Review
Department of Microbiology, Taligene Pars Company, Isfahan Science and Technology Town, Isfahan, Iran
The discovery of antibiotics followed by the extensive production of new antibiotics and their widespread use in the treatment of bacterial infectious diseases has led to bacterial resistance to antibacterial agents. Despite global efforts to improve the status of antimicrobial treatment, the phenomenon of resistance against gram-negative bacteria has increased in communities and hospitals. Pseudomonas aeruginosa, the most common human pathogen, is an oxidase-positive and glucose non-fermentative gram-negative bacillus considered an important opportunistic pathogen and the cause of mortality in patients with cystic fibrosis, neoplasms, and severe burns. Infection caused by Pseudomonas aeruginosa is one of the most important complications in hospitalized patients, and its incidence is increasing significantly in developed and developing countries. Based on the literature, it can be concluded that antibiotic resistance is higher in developing countries than developed ones, which is likely due to excessive antibiotic use in developing countries or the control of antibiotic use in developed ones.