Pyroptosis in Cancer Cells and its Perspectives in Nanomedicine

Document Type : Mini Review


1 Laboratory of Urogenital Carcinogenesis and Immunotherapy, Department of Structural and Functional Biology, University of Campinas, Campinas, SP, Brazil

2 Nanomedicine Research Unit (Nanomed), Federal University of ABC (UFABC), Santo André, Brazil


Pyroptosis is a cell death mechanism that appears as an inflammatory form of cell death triggered by inflammasomes and disrupts a human protein encoded by the GSDMD gene in chromosome 8 (Gasdermin D) and by cytokine activation. Scientific facts have already indicated that the association between pyroptosis and cancer is extremely complicated, since pyroptosis´ effects on cancer cells can change depending on the affected tissues and genetic differences. For example, pyroptosis can inhibit tumor progress; however, as a pro-inflammatory process, it can create an appropriate microenvironment for tumor growth. Nevertheless, literature in this field has recently addressed important cancer treatment perspectives enabled by this process. The aim of the current study was to address a new nanomedicine aspect associated with pyroptosis.