Clinical Trial of Combined Thymus daenensis Celak and Ziziphus Jujube Mill Syrup in Primary Hypertension

Document Type : Original Article


1 Department of Persian Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

2 Department of Cardiology, Zanjan University of Medical Sciences, Zanjan, Iran

3 Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

4 University of Sistan and Baluchestan, Zahedan, Iran

5 School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

6 Department of Biostatistics and Epidemiology, Zanjan University of Medical Sciences, Zanjan, Iran


 Introduction: Hypertension is the most important disease that can cause heart failure, renal dysfunction, stroke and sodden death in a large population throughout the world. The excessive side effects of the chemical drugs that are used in the treatment of hypertension have attracted attention to herbal medicine.
Methods: This study was designed as a randomized clinical trial on both males and females with first and second stage of hypertension. The patients who met inclusion criteria and none of the exclusion criteria were enrolled in the study. The patients were allocated with random blocked dividing between the case and control group with the same group size. The patients in the control group used placebo and patients in case group used mixed therapeutic syrup of Ziziphus Jujube and Thymus daenensis Celak. The syrup was used twice a day with a dose of 5 ml for each time. In order to study the effects of Ziziphus and Thymus on blood biomarkers, it was checked in two stages.
Results: Findings reveal that the mixture of herbal syrup could significantly reduce Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) in hypertensive patients (p = 0.002). The reduction in SBP and DBP at the end of the study was 11.84 and 8.03 mmHg, respectively. Also, the mean arterial pressure compared to the baseline decreased to 8.35%. Regards to other parameters, the results of the experiments at the beginning and end of the study showed that Complete Blood Count (CBC), Fasting Blood Sugar (FBS), cholesterol, low-Density Lipoproteins (LDL), High-Density Lipoprotein (HDL), Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP), Blood Urea Nitrogen (BUN), and creatinine were in the normal laboratory range.
Conclusion: According to results it can be stated that jujube and thyme can be considered as a miraculous combination in  Cardiovascular Disease, Persian Traditional Medicine, Blood Pressure, Thymus Daenensis, Ziziphus Jjujube
controlling blood pressure, to minimize secondary complications caused by hypertension.