Liquid biopsy as a new rising non-invasive testing method plays an important role in assist of the diagnosis, evaluation of the efficacy and prognosis, monitoring of early recurrence and drug resistance. It has been widely applied in some type of solid tumors. Lymphoma is a group of heterogeneous hematological malignancies which most subtypes without specific tumor markers and evaluation of the efficacy and prognostic is mainly depends on and limited to biopsy and imaging. Compared to other solid tumors, lymphoma tumor cells were characterized with access to peripheral easier and immunoglobulin molecules diversity can be monitored as marker, which is more applicable to liquid biopsy. With advances in the detection technology, research and application of liquid biopsy in lymphoma has attracted more attentions.