Anti-Depressant Effects of Palmitic Acid: The Necessity of Focusing on New Agents



Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran


Loss of interest in usual activities, dysphoric mood, and other psychiatric signs and symptoms are defined as depression, which has a strong association with many diseases and increases mortality rates. Major Depressive Disorder (MDD) is a common psychiatric disorder. The prevalence of MDD has been determined to be 15%-25%. Recent epidemiologic studies have indicated that depression and its side effects are increasing in different societies. Drugs commonly prescribed for the management of depression include: tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRI), and monoamine oxidase enzyme inhibitors (MAOI). Many new drugs have recently been approved, such as Nefazodone and Bupropion... (Read more...)

  1. Sadock B, Sadock V. Mood disorders. In: Blazer D, editor. Kaplan & Sadock comprehensive textbook of psychiatry. 7th2000. p. 1298-30.
  2. Kaplan H, Sadock B, Grebb T. Synopsis of psychiatry. 8th. Maryland: Lippincott Williams & Wilkins; 1998.
  3. Brunton LL, Chabner B, Knollmann BC. Goodman & Gilman's the pharmacological basis of therapeutics: McGraw Hill companies; 2011.
  4. Abraham SK. Anti-genotoxicity of trans-anethole and eugenol in mice. Food Chem Toxicol. 2001;39(5):493-8.
  5. Cavalcanti JM, Leal-Cardoso JH, Diniz LR, Portella VG, Costa CO, Linard CF, et al. The essential oil of Croton zehntneri and trans-anethole improves cutaneous woundhealing. J Ethnopharmacol. 2012;144(2):240-7. doi:10.1016/j.jep.2012.08.030.
  6. Gunstone FD, Harwood JL, Dijkstra AJ. The lipid handbook with CD-ROM: CRC press; 2007.
  7. Najafizadeh-Sari S, Khosravi MH. Vitamin D and viral hepatitis: the new issue in pathogenesis and outcomes. Int J Med Rev. 2017;3(3):457-68. doi:10.15171/IJMR.2016.01.
  8. Tsuboi H, Watanabe M, Kobayashi F, Kimura K, Kinae N. Associations of depressive symptoms with serum proportions of palmitic and arachidonic acids, and alpha-tocopherol effects among male population--a preliminary study. Clin Nutr. 2013;32(2):289-93. doi:10.1016/j.clnu.2012.07.011.
  9. Banerjee P, Dawson G, Dasgupta A. Enrichment of saturated fatty acid containing phospholipids in sheep brain serotonin receptor preparations: use of microwave irradiation for rapid transesterification of phospholipids. Biochim Biophys Acta. 1992;1110(1):65-74. doi:10.1016/0005-2736(92)90295-W.
  10. Contreras A, Del Rio D, Martinez A, Gil C, Morales L, Ruiz-Gayo M, et al. Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3? Neuroreport. 2017;28(6):354-9. doi:10.1097/WNR.0000000000000774.
  11. Gopal S, Gassmann-Mayer C, Palumbo J, Samtani MN, Shiwach R, Alphs L. Practical guidance for dosing and switching paliperidone palmitate treatment in patients with schizophrenia. Curr Med Res Opin. 2010;26(2):377-87. doi:10.1185/03007990903482772.
  12. Crupi R, Paterniti I, Ahmad A, Campolo M, Esposito E, Cuzzocrea S. Effects of palmitoylethanolamide and luteolin in an animal model of anxiety/depression. CNS Neurol Disord Drug Targets. 2013;12(7):989-1001.
  13. Scapagnini G, Davinelli S, Drago F, De Lorenzo A, Oriani G. Antioxidants as antidepressants: fact or fiction? CNS Drugs. 2012;26(6):477-90. doi: 10.2165/11633190-000000000-00000.